Ī meta-analysis published in the journal Molecules identified 35 randomized controlled trials investigating inositol on PCOS. With the combined administration of both myo-inositol and DCI in a 40:1 ratio, could enhance fertility for women with PCOS seeking pregnancy. MI is a second messenger of follicle-stimulating hormone (FSH) and DCI is an aromatase inhibitor. Myo-Inositol has been shown to help restore ovulation in women with PCOS. Treatment duration however is critical to help alleviate symptoms requiring a minimum of 6 months to see an overall reduction. Research has shown that inositol may reduce testosterone levels and aid in reducing androgen levels. This promotes hyperandrogenism and reduces the efficiency of MI-mediated FSH signaling. In the polycystic ovary, systemic insulin resistance (hyperinsulinemia) accentuates epimerase activity, thus creating a higher DCI-to-MI ratio. In the normal ovary, these activities proceed in balance, allowing the maintenance of normal hormonal levels and facilitating ovarian function. MI supports FSH signaling, whereas DCI is responsible for insulin-mediated testosterone synthesis. In the ovary, MI and DCI have specific duties to perform. It is suggested that the inositol MI and DCI reduce insulin resistance, improve ovarian function, and reduce androgen levels in women with PCOS. There are nine forms of inositol, but research suggests that the two that have the biggest impact on PCOS are myo-inositol (MI) and D-chiro-inositol (DCI). This is the main rationale suggesting the use of inositol in the management of insulin resistance syndromes, such as polycystic ovary syndrome (PCOS). Defects in this pathway can lead to impaired insulin signaling and cause insulin resistance. Present also in foods such as fruits and beans Inositol helps balance hormones and is a secondary messenger for insulin. Inositol more commonly referred to as Vitamin B8, is a pseudo vitamin and a kind of sugar made by the body. Too much insulin can alter the luteinizing hormone increasing ovarian androgen production. The ovary is very sensitive to the effects of insulin and is immune to insulin resistance. Benefits Of Inositol For PCOS Inositol May Improve Insulin Resistance Vitamins are considered essential nutrients because the body cannot synthesize enough of them to meet bodily requirements and therefore must be obtained through food or supplements. Inositol is a type of sugar alcohol and considered a pseudovitamin because it is a nonessential nutrient. Inositol also known as Vitamin B8 is a naturally occurring sugar and is also found in a variety of foods such as fruits, grains, beans, and organ meats. Evidence also shows that PCOS could be hereditary. Excess insulin might increase androgen production, causing difficulty with ovulation. If you become resistant to insulin then your blood sugar levels rise and your body will produce more insulin in response. Insulin is a hormone produced in the pancreas that allows your body to regulate and use sugar for energy. Researchers purport that excess insulin may be a potential cause of PCOS. Although the exact cause is unknown, you can manage PCOS to alleviate symptoms and mitigate the risk of diabetes with specific supplements for PCOS. Women with PCOS may have irregular menstrual cycles and elevated levels of the male hormone androgen. Polycystic Ovary Syndrome (PCOS) is a hormonal imbalance disorder. Inositol referred to as Vitamin B8 is one of the ways to help alleviate PCOS and the research has shown promising results. However, there are natural ways to alleviate symptoms. Although the paucity of cause is relatively unknown, there is no cure for PCOS.
PCOS affects 1 out of every 10 women of childbearing age and can lead to associated health problems like diabetes and infertility. Polycystic ovary syndrome (PCOS) is caused by a hormonal imbalance.
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